Description
A multikinase inhibitor with IC50 of 21nM and 15nM for Aurora A/TPX2 and Aurora B/INCENP respectively; inhibits 56 kinases (IC50<100nM); inhibits kinds of cancer cell lines with EC50s of 40-500nM; suppresses cellular histone H3 phosphorylation and induced polyploidy. Blood Cancer Phase 1 Discontinued